Antibacterial and Cytotoxic Activities of Extracts and Isolated Compounds of Ipomoea turpethum
نویسندگان
چکیده
Three compounds H-1 ($-sitosteryl-$-D glucoside), H-2 (22, 23-dihydro-"-spinosteryl glucoside) & CH-2 (salicylic acid) isolated from the chloroform extract of stem of Ipomoea turpethum and the crude petroleum ether, chloroform and ethyl acetate extracts were screened against thirteen pathogenic bacteria for their antibacterial activities. The minimum inhibitory concentration (MIC) of the isolated compound CH-2 was also measured against Bacillus subtilis, Shigella dysenteriae, Sarcina lutea and Escherichia coli. The values were found to be between 128 and 256 μg/ml. The cytotoxic activity of CH-2 and chloroform and ethyl acetate extracts was also measured by brine shrimp lethality bioassay and the LC values were found 50 to be 56.23, 199.53 and 31.62 μg/ml, respectively.
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